Delta-9-Tetrahydrocannabinol (Δ9-THC) is the primary psychoactive cannabinoid in cannabis, widely discussed for its capacity to produce euphoria, relaxation, and laughter. Research shows that it binds strongly to CB₁ receptors in the brain, which drives much of its “high.” However, at higher doses, Δ9-THC often triggers anxiety, fear, and even panic.

Moreover, a clinical trial using intravenous Δ9-THC in healthy individuals (2.5–5 mg) reported acute anxiety, along with euphoria and perceptual changes.

Importantly, newer research indicates that very high-potency THC products (common in modern cannabis concentrates) are linked to unfavorable mental-health outcomes, including anxiety — particularly when used recreationally rather than therapeutically.